Toxicity Vinyl Acetate

Acute short term inhalation exposure of workers to vinyl acetate has resulted in eye irritation and upper respiratory tract irritation.

Toxicity vinyl acetate.

Vinyl acetate is primarily used as a monomer in the production of polyvinyl acetate and polyvinyl alcohol. On january 31 2009 the government of canada s final assessment concluded that exposure to vinyl acetate is not harmful to human health. Lc50 guinea pig inhalation 21800 ppm 4 hr. Vinyl acetate is an industrial chemical that is produced in large amounts in the united states.

Iarc lc50 mouse inhalation 5150 ppm 4 hr. 108 05 4 non human toxicity values. It is a clear colorless liquid with a sweet fruity smell. This website and underlying databases are maintained and updated by pesticide action network north america pan.

The toxicity and carcinogenicity of vinyl acetate is related to its extensive rapid metabolic conversion to acetaldehyde and acetic acid with concomitant production of tissue acidifying protons. For rats oral ld50 is 2920 mg kg. Metabolic clearance of acetaldehyde and acetic acid as well as processes controlling cellular ph serve to reduce tissue exposure to these metabolites providing some protection against toxicity. Vinyl acetate cas rn.

Vinyl acetate does not warrant labelling according to eu criteria with respect to acute oral and acute dermal toxicity. Vinyl acetate identification toxicity use water pollution potential ecological toxicity and regulatory information. Other pertinent literature is also presented but is described in less detail than the key studies. See working with the information on this page section below for important notes about this data.

Tests suggest that vinyl acetate is of low toxicity. Lc50 rat inhalation 3680 ppm 4 hr. According to the agency for toxic substances and disease registry there is no evidence to show that vinyl acetate is a human carcinogen although the international agency for research on cancer believes there is some limited evidence that it is possibly carcinogenic to humans 3. The atsdr toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here.

Inhalation toxicity testing in rats for 4 hours determined lc50 values of 15810 mg m and 14084 mg m therefore classification as cat 4 h332 harmful if inhaled according to regulation ec no 1272 2008.